Centro de Química

Publicações

Artigo

Sodium alginate/polycaprolactone co-axial wet-spun microfibers modified with N-carboxymethyl chitosan and the peptide AAPV for Staphylococcus aureus and human neutrophil elastase inhibition in potential chronic wound scenarios

Catarina S. Miranda; A. Francisca G. Silva; Catarina L. Seabra; Salette Reis; M. Manuela P. Silva; Sílvia M.M.A. Pereira-Lima; Susana P.G. Costa; Natália C. Homem; Helena P. Felgueiras

Biomaterials Advances , 2023

Artigo

Tiger 17 Peptide Loaded Polycaprolactone/Cellulose Acetate Electrospun Nanofibrous Mats For Applications In Cutaneous Wound Dressings

Sílvia Pereira-Lima; Ana R. M. RIBEIRO; Marta A. TEIXEIRA; Susana P. G. COSTA; Helena P. FELGUEIRAS

Tekstil ve Mühendis , 2022

Artigo

Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

Catarina S. Miranda; Ana Francisca G. Silva; Sílvia M. M. A. Pereira-Lima; Susana P. G. Costa; Natália C. Homem; Helena P. Felgueiras

Pharmaceutics , 2022

Artigo em Ata

Synthesis of Peptaibolin, an Antimicrobial Peptide

Ana R. M. Ribeiro; Helena P. Felgueiras; Susana P. G. Costa; Sílvia M. M. A. Pereira-Lima; Ana R. M. Ribeiro; Helena P. Felgueiras; Susana P. G. Costa; Sílvia M. M. A. Pereira-Lima

2020

Artigo em Ata

Industrial engineering and management PBL implementation: An effortless experience?

Alves, A.C.; Moreira, F.; Leão, C.P.; Pereira, A.C.; Pereira-Lima, S.M.M.A.; Malheiro, M.T.; Lopes, S.O.; Oliveira, S.; Alves, A.C.; Moreira, F.; Leão, C.P.; Pereira, A.C.; Pereira-Lima, S.M.M.A.; Malheiro, M.T.; Lopes, S.O.; Oliveira, S.

International Symposium on Project Approaches in Engineering Education , 2019

Artigo

Peptaibolin analogues by incorporation of α,α-dialkylglycines: Synthesis and study of their membrane permeating ability

Castro, V.I.B.; Carvalho, C.M.; Fernandes, R.D.V.; Pereira-Lima, S.M.M.A.; Castanheira, E.M.S.; Costa, S.P.G.

Tetrahedron , 2016

Artigo em Ata

Permeation of model membranes by Peptaibolin mimetics bearing different a,a-dialkylglycines

Carvalho, Carina Martins; Castro, Vânia Isabel Baptista; Pereira-Lima, Sílvia M. M. A.; Castanheira, Elisabete M. S.; Costa, Susana P. G.

2016

Artigo em Ata

Membrane active peptides with unnatural amino acids: permeation studies in model membranes

Carvalho, Carina Martins; Castro, Vânia Isabel Baptista; Pereira-Lima, Sílvia M. M. A.; Castanheira, Elisabete M. S.; Costa, Susana P. G.

2015

Artigo em Ata

Peptide-induced permeation of model membranes by antimicrobial peptidomimetics

Carvalho, Carina Martins; Castro, Vânia I. B.; Pereira-Lima, Sílvia M. M. A.; Costa, Susana P. G.; Castanheira, Elisabete M. S.

2015

Artigo

Synthesis of dehydrodipeptide and N-ethyl-dehydrodipeptide derivatives with an α-aminoisobutyric acid residue

Monteiro, L.S.; Pereira-Lima, S.M.; Pereira, S.; Monteiro, L.S.; Pereira-Lima, S.M.; Pereira, S.

Current Chemical Biology , 2014

Artigo

Synthesis of N-alkyl-C^α,α-dimethylglycine derivatives

Monteiro, L.S.; Pereira-Lima, S.M.M.A.; Pereira, S.; Machado, J.N.; Monteiro, L.S.; Pereira-Lima, S.M.M.A.; Pereira, S.; Machado, J.N.

Arkivoc , 2014

Artigo em Ata

Optimizations studies on the microwave assisted synthesis of antimicrobial Peptaibols

Castro, Vânia I. B.; Carvalho, Carina Martins; Fernandes, Rui D. V.; Aguiam, Nádia; Costa, Susana P. G.; Pereira-Lima, Sílvia M. M. A.

2013

Artigo

α,α-Dialkylglycines obtained by solid phase Ugi reaction performed over isocyanide functionalized resins

Aguiam, N.R.; Castro, V.I.; Ribeiro, A.I.F.; Fernandes, R.D.V.; Carvalho, C.M.; Costa, S.P.G.; Pereira-Lima, S.M.M.A.

Tetrahedron , 2013

Artigo em Ata

Synthesis of a-tetrasubstituted amino acids by solid phase ugi reaction using isocyanide amino acid derivatives as resin spacers

Ribeiro, Ana Isabel F.; Aguiam, Nádia R.; Costa, Susana P. G.; Lima, Sílvia M. M. A. Pereira

2012

Artigo em Ata

Synthesis of mimetics of peptaibolin, an antimicrobial peptide, by incorporation of unnatural amino acids

Fernandes, Rui D. V.; Aguiam, Nádia R.; Lima, Sílvia M. M. A. Pereira; Costa, Susana P. G.; Fernandes, Rui D.V.; Aguiam, Nadia R.; Pereira-Lima, Sílvia M. M. A.; Costa, Susana P.G.

2011

Artigo

Straightforward, racemization-free synthesis of peptides with fairly to very bulky di- and trisubstituted glycines

Pinto, F.C.S.C.; Pereira-Lima, S.M.M.A.; Maia, H.L.S.; Pinto, F.C.S.C.; Pereira-Lima, S.M.M.A.; Maia, H.L.S.

Tetrahedron , 2009

Artigo

Synthesis and kinetic investigation of the selective acidolysis of para-substituted N-benzyl- or N-phenyl-N-phenylacetyl-α,α-dialkylglycine cyclohexylamides

Pinto, F.C.S.C.; Pereira-Lima, S.M.M.A.; Ventura, C.; Albuquerque, L.; Gonçalves-Maia, R.; Maia, H.L.S.; Pinto, F.C.S.C.; Pereira-Lima, S.M.M.A.; Ventura, C.; Albuquerque, L.; Gonçalves-Maia, R.; Maia, H.L.S.

Tetrahedron , 2006

Artigo em Ata

Investigation of structure-reactivity relationships in the acidolysis of alpha,alpha-dialkyl glycine derivatives

Pereira-Lima, Sílvia M.M.A. ; Jiang, Wei-Qun; Ventura, Cristina; Albuquerque, Lídia; Maia, Raquel M. Gonçalves; Maia, Hernâni L. S.

Peptides 2004 - Bridges Between Disciplines , 2005

Artigo

Kinetic investigation of the effect of the amino acid side chains in the selective acidolysis of N-acyl-N,α,α-trialkyl glycine amides

Jiang, W.-Q.; Pereira-Lima, S.M.M.A.; Ventura, C.; Costa, S.P.G.; Albuquerque, L.; Gonçalves-Maia, R.; Maia, H.L.S.; Jiang, W.-Q.; Pereira-Lima, S.M.M.A.; Ventura, C.; Costa, S.P.G.; Albuquerque, L.; Gonçalves-Maia, R.; Maia, H.L.S.

Journal of Peptide Science , 2005

Artigo

An improved approach for the synthesis of α,α-dialkyl glycine derivatives by the Ugi-Passerini reaction

Costa, S.P.G.; Maia, H.L.S.; Pereira-Lima, S.M.M.A.; Costa, S.P.G.; Maia, H.L.S.; Pereira-Lima, S.M.M.A.

Organic and Biomolecular Chemistry , 2003

Ver mais

Equipa

Silvia Manuela Lima

ORCID

CIÊNCIA VITAE

SCOPUS ID

Publicações

25

H-index

7

Estudantes PhD

0

Projetos

4

Publicações

Sodium alginate/polycaprolactone co-axial wet-spun microfibers modified with N-carboxymethyl chitosan and the peptide AAPV for Staphylococcus aureus and human neutrophil elastase inhibition in potential chronic wound scenarios

Tiger 17 Peptide Loaded Polycaprolactone/Cellulose Acetate Electrospun Nanofibrous Mats For Applications In Cutaneous Wound Dressings

Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

Synthesis of Peptaibolin, an Antimicrobial Peptide

Industrial engineering and management PBL implementation: An effortless experience?

Peptaibolin analogues by incorporation of α,α-dialkylglycines: Synthesis and study of their membrane permeating ability

Permeation of model membranes by Peptaibolin mimetics bearing different a,a-dialkylglycines

Membrane active peptides with unnatural amino acids: permeation studies in model membranes

Peptide-induced permeation of model membranes by antimicrobial peptidomimetics

Synthesis of dehydrodipeptide and N-ethyl-dehydrodipeptide derivatives with an α-aminoisobutyric acid residue

Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives

Optimizations studies on the microwave assisted synthesis of antimicrobial Peptaibols

α,α-Dialkylglycines obtained by solid phase Ugi reaction performed over isocyanide functionalized resins

Synthesis of a-tetrasubstituted amino acids by solid phase ugi reaction using isocyanide amino acid derivatives as resin spacers

Synthesis of mimetics of peptaibolin, an antimicrobial peptide, by incorporation of unnatural amino acids

Straightforward, racemization-free synthesis of peptides with fairly to very bulky di- and trisubstituted glycines

Synthesis and kinetic investigation of the selective acidolysis of para-substituted N-benzyl- or N-phenyl-N-phenylacetyl-α,α-dialkylglycine cyclohexylamides

Investigation of structure-reactivity relationships in the acidolysis of alpha,alpha-dialkyl glycine derivatives

Kinetic investigation of the effect of the amino acid side chains in the selective acidolysis of N-acyl-N,α,α-trialkyl glycine amides

An improved approach for the synthesis of α,α-dialkyl glycine derivatives by the Ugi-Passerini reaction

Projetos

Desenho baseado na estrutura, atividade biológica e estudos de permeação de membrana modelo de peptaibols antimicrobianos com aminoácidos não naturais

Investigação de modificações miméticas de péptidos bioativos por inclusão de aminoácidos sintéticos

Péptido CW49 como potencial agente antimicrobiano contra as bactérias colonizadoras mais prevalentes em úlceras do pé diabético

Filmes nanofibrosos eletrofiados sensíveis a pH e modificados com o péptido WAAPV inibem a ação de bactérias e de enzimas proteolíticas em úlceras do pé diabético.

Estudantes PhD

Synthesis of N-alkyl-C^α,α-dimethylglycine derivatives